Just finished the commentary. Most fun. With the number of commentators, it was almost a case of too many cooks wishing to spoil the schlock.

The production design was universally praised as a sole positive, but I would separate out the VFX from the design.

On the positive side, the entire atmosphere entry and landing sequence is gorgeous. Maybe the most jaw-dropping landing sequence ever. The crash in the finale is also most impressive.

On the negative side, the interior of the Prometheus is fairly bog-standard. The space-suits are meh. The dirt strip between the landing site and the first Engineer croissant is like a quarry (and this was the setting for most of action & movement) and the Giger interiors we've seen before and got repetitive. The med-pod had salad tongs. And the creature design throughout was uninspired. And, as stated, the make up job on Weyland was amateurish.
In other words, take out the scenes where the ships are air-borne, and it's a very ordinary looking movie.