Well, after a quick read of the AFI list, I can proudly say I have seen the vast majority of them. 

But there are some classics I have not seen...

1.  Rocky
2.  Lawrence of Arabia
3.  On the Waterfront
4.  A Streetcar Named Desire
5.  West Side Story
6.  Giant

1)  Caché
2)  Amadeus
3)  The Wild Bunch
4)  Sunset Blvd.
5)  Gandhi

That AFI list is ok as a guide if you know nothing about movies but it's kinda silly.
Some Like It Hot 14th - Annie Hall 31st?
All About Eve 16th - Pulp Fiction 95th?
The African Queen 17th - Raiders of the Lost Ark 60th?

Trey you should watch Rocky soon, if only to hear Burgess Meredith say "hehe... digs his locker".

@Zarban

1. Never seen Schindler's.
2. There Will Be Blood is pretty much what you expect. Sort of compelling, very long, pretty, and worth is for Daniel Day Lewis' vocal affectation.
3. One Flew is actually pretty fucked up. Goes to the mansion a couple times, but comes back. Ultimately a good movie.
4. I lived in Arkansas. Don't talk to me.
5. Clerks is tiring; to me, it's like Annie Hall. You can legitimately say you've seen the whole thing after watching half an hour.
6. Happy Gilmore and The Wedding Singer are awesome, Big Daddy and Billy Madison are fun for their character performances, The Waterboy and Eight Crazy Nights are kind of retarded. The rest are the rest.

Didn't care for Punch Drunk Love.

"The list is long, but distinguished"
                                   - Goose

1) Jaws
2) Animal House
3) Blues Brothers
4) It's a Wonderful Life
5) Breakin' 2: Electric Boogaloo

Titanic was on my list by choice, however, i caught it on a flight back from London once.  I'm guessing Airport '77 wasn't available

Seinfeld might be the greatest sitcom ever made.  The only show that even rivals it is The Cosby Show.

- Branco