I had a discussion with the gf yesterday about comic book movies, why they work/don't work, and Fantastic four was listed as one that doesn't.
I think the main problem with F4, Hulk, Thor and Green Lantern, is that the premise works as a comic book, where the story doesn't need to wrap within a set time frame, but can easily span over several years. A movie always needs to deal with the origin story, an obstacle, and a resolution.
F4 made no sense at all, unless you've read the comic book, hulk COULD work, but I don't see how, to be honest. Thor raped Norse mythology. As for Green Lantern... Well, that shit is just weird any way you look at it. A guardian of the universe that uses a ring that replicates any object in green glass-esque material? WTF.